miRNA-1183-targeted regulation of Bcl-2 contributes to the pathogenesis of rheumatic heart disease
نویسندگان
چکیده
منابع مشابه
Animal Models to Investigate the Pathogenesis of Rheumatic Heart Disease
Rheumatic fever (RF) and rheumatic heart disease (RHD) are sequelae of group A streptococcal (GAS) infection. Although an autoimmune process has long been considered to be responsible for the initiation of RF/RHD, it is only in the last few decades that the mechanisms involved in the pathogenesis of the inflammatory condition have been unraveled partly due to experimentation on animal models. R...
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BACKGROUND RHD is an autoimmune disease that arises following infection by S. pyogenes and imposes a heavy burden on public health. MATERIAL AND METHODS We detected 11 selected miRNAs expressed in the cardiac tissues of 11 RHD patients and 11 controls. By employing dual-luciferase assay and Western blot, we identified the relationship between TLR2 and miR-101 and miR-101. We used ELISA to tes...
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Background/Objective: To clarify the state of different immunologic factors in patients with acute rheumatic fever (ARF) and rheumatic heart disease (RHD) compared to healthy individuals.Patients and Methods: Patients with ARF (#21), patients with RHD six months after the onset of ARF (#19), and healthy children from the same age group with normal physical examination and no history of pharyngi...
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Molecular mimicry is a hallmark of the pathogenesis of rheumatic fever where the streptococcal group A carbohydrate epitope, N-acetyl glucosamine, and the a-helical coiled-coil streptococcal M protein structurally mimic cardiac myosin in the human disease, rheumatic carditis, and in animal models immunized with streptococcal M protein and cardiac myosin. Recent studies have unraveled the potent...
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نظر به اهمیت و تاثیر روزافزون عوامل روانی – اجتماعی در سلامت جسمی و تاثیر عوامل روان شناختی در بروز بیماریهای مختلف از جمله بیماریهای قلبی و عروقی این پژوهش با هدف کلی بررسی ارتباط تیپ شخصیتی d ، حمایت اجتماعی و خود دلسوزی در پیش بینی رفتارهای بهداشتی بیماران کرونر قلبی و تعیین تفاوت بین بیماران کرونر قلبی با و بدون جراحی و افراد سالم در این متغیرها و رفتارهای بهداشتی آنان، انجام گرفت. جامعه آ...
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ژورنال
عنوان ژورنال: Bioscience Reports
سال: 2020
ISSN: 0144-8463,1573-4935
DOI: 10.1042/bsr20201573